France, 15th century. Michel de Nostradamus, Europe's most famous prophet, receives a strange letter wrapped in secrecy from his old friend Gregory. The latter asks him to come to him as soon as possible. As soon as he arrives at the place, he discovers that the evil spirits have cursed his friend's house. After completing the alchemical ritual to free the house of the spell, Nostradamus has visions of four horsemen who will come to destroy our world.